Blisters on the palms of the hands may be a symptom of friction blisters, burns, sweat blisters or ringworm, and need to go to the dermatology department of the hospital in time for a clear diagnosis. 1. Friction blisters are caused by repeated friction of the skin on the hands, mostly seen after tug-of-war and other sports activities or heavy physical labor. The performance of the hand has a bean grain to coin size blisters, blisters blister wall is thicker, the surface is loose, no obvious discomfort. 2. Scald is the skin of the hand in contact with hot water or hot oil and other high temperature objects caused by the performance of the palm of the skin vesicles and more than one transparent blisters, blister wall tension, accompanied by different degrees of pain. 3. Sweat herpes etiology is unknown, may be related to local allergies, skin infections, mental factors, etc., the performance of both hands symmetrically appeared in the deep subcutaneous blisters of grain size, blisters opaque, itching obvious. 4. Ringworm is caused by fungal infection, transmitted through skin contact. Performance for the palm of the skin appeared intensive subcutaneous blisters, blisters are easy to dry up the formation of flaking, itching obvious, can gradually spread to other parts. There may be other reasons for the blisters on the palms of the hands, it is recommended to go to the hospital in time, clear diagnosis, symptomatic treatment.