Possible causes of long-term dyspepsia include physiological factors such as emotions, diet, bad habits and pathological factors such as chronic gastritis, peptic ulcer and gastroesophageal reflux disease. 1. Physiological factors: frequent dramatic changes in mood, long-term depression, stress and anxiety can lead to gastrointestinal dysfunction, resulting in long-term dyspepsia; poor dietary habits, such as overeating, diet is not regular and so on, can also lead to long-term dyspepsia; long-term smoking, drinking, staying up all night and other addictions will also lead to long-term dyspepsia. 2. Pathological factors: peptic ulcer, gastroesophageal reflux disease, chronic gastritis and other diseases can lead to dysfunction of the digestive system, causing long-term dyspepsia; Helicobacter pylori infection and other diseases can cause intestinal dysbiosis, leading to gastrointestinal dysfunction, causing long-term dyspepsia. Patients should pay close attention to their conditions, improve their lifestyles, and seek prompt medical attention if symptoms cannot be relieved in time to avoid delaying their conditions.