Total bleeding after leuprolide injection may be a normal phenomenon; of course, we should also exclude vaginal bleeding caused by other diseases, it is recommended to go to the hospital for follow-up examination. Leuprolide injection can be used to treat endometriosis, uterine fibroids, premenopausal breast cancer with estrogen receptor positive, central precocious puberty, in addition to the treatment of male prostate cancer. Leuprolide is a gonadotropin-releasing hormone agonist that promotes the release of luteinizing hormone and follicle-stimulating hormone, followed by a sustained inhibition of the pituitary gland’s secretion of gonadotropins. Shortly after injection use, it can make uterine fibroids shrink rapidly, reduce surgical bleeding, and help postoperative recovery; it can also make ovarian function inhibition and achieve amenorrhea. In some patients, the application of leuprolide may result in a small amount of vaginal bleeding, which can usually be stopped naturally after the second injection. However, in case of continuous bleeding, it is necessary to go to the gynecologist as soon as possible to improve the examination to exclude some malignant diseases, such as endometrial cancer, which can also cause irregular vaginal bleeding. The use of leuprolide may have some adverse reactions, common digestive discomfort symptoms, endocrine disorders, a few patients appear shoulder and waist and limb pain, urinary disorders, hematuria, cardiac arrhythmia and so on. This drug is contraindicated in people with a history of allergy to the components of the drug, pregnant or breastfeeding women; it is contraindicated in patients with abnormal vaginal bleeding of unknown nature. The drug is used by subcutaneous injection, the injection site of the upper arm, abdomen or buttocks can be selected, do not rub the injection site after injection.