50-year-old male breast gland development, may be related to excessive secretion of estrogen, in taking antibiotic hormone drugs, or suffering from hyperthyroidism, testicular spermatogonia, etc., may lead to estrogen and androgen level disorders, easy to cause abnormal development of the mammary glands. 1. Use of anti-androgen drugs: When men suffer from baldness due to exuberant secretion of androgen, if they need to take anti-androgen drugs for a long period of time, it may lead to a decrease in the level of androgen and an increase in the level of estrogen, which may cause abnormal development of the mammary glands when the level of estrogen and androgen is disturbed. 2. Hyperthyroidism: also known as hyperthyroidism, when the thyroid hormone level is disturbed, resulting in a decrease in androgen level and an increase in estrogen level, it will also cause abnormal development of the mammary glands. 3. Testicular spermatogonia: It is a kind of tumor that occurs at the testis and originates from spermatogonia. This disease is also related to estrogen and androgen level disorder, which will cause abnormal breast development if not regulated in time. Abnormal development of breast glands in 50-year-old men, it is recommended to consult a doctor in time, and then through the test hormone levels to understand the situation, if there is a decline in androgens, estrogen rise, should be timely under the guidance of the physician for hormone replacement therapy to supplement androgen as the main principle.