Whether lupus erythematosus can be vaccinated with the new coronavirus vaccine needs to be analyzed according to the different periods of the disease, and the vaccine can be administered during the stable period. 1. Stable stage: Lupus erythematosus is not a contraindication to the vaccination with the new coronavirus vaccine, so after the patient’s condition has stabilized after active treatment, and it is clear that the patient does not have any allergic symptom to the vaccine components, he/she can cautiously receive the new coronavirus vaccine after a comprehensive evaluation by a specialist. 2. Acute stage: If the patient is in the acute flare-up stage of the disease, which is often manifested by the emergence of new skin rashes, redness, swelling and pain in the joints, or symptoms of respiratory and gastrointestinal tract infections, or unexplained elevation of the blood sedimentation rate, the heterologous protein components contained in the XKV vaccine may cause aggravation of the symptoms of lupus erythematosus, and therefore, the patient should not be vaccinated at this point in time. It is recommended that patients with lupus erythematosus should first go to a regular hospital for consultation, and a specialist will assess whether the vaccine is suitable for them according to their conditions.