Paracetamol (chlorpheniramine maleate) and ibastine are a generation of antihistamines and second-generation antihistamines, respectively, for hives, eczema, dermatitis and other causes of itching skin, will improve, the main difference between the two is that the drug side effects are different. 1. Chlorpheniramine maleate: this is a generation of antihistamines, the drug has a certain inhibition of the central role, can cause drowsiness, drowsiness, so for overhead workers, drivers, etc. try not to recommend taking. 2. Ebastine: Ebastine is a second-generation antihistamine, which has no antagonistic effect on cholinergic receptors in the central nervous system. It is a potent, long-acting, highly selective histamine receptor blocker. For the choice of the two drugs, patients are advised to use them under the guidance of a doctor to avoid adverse reactions.