Having plague usually requires treatment for 10 to 20 days, during which it should be strictly isolated. In addition to this, 7 days of observation and 6 negative sputum cultures are required for recovery. The main types of plague are adenomatous plague, pneumonic plague, septicemic plague, mild plague, etc. It is mainly treated with streptomycin, and the treatment course is about 10~20 days, and the serious cases need a longer period of time. If streptomycin is allergic to the disease, aminoglycosides and fluoroquinolones can be used for the treatment, and the drugs should be chosen according to the instruction of the doctor, and the drugs should be examined timely if there is any discomfort and changed for the drug treatment. During the treatment period, strict rest should be taken, isolated in an environment without rats and fleas, and sterilized at regular intervals. Meanwhile, those with adenomatous plague should be isolated until the lymph node enlargement is completely dissipated and then observed for 7 days, and patients with pneumonic plague need to have 6 negative sputum cultures. The population is generally susceptible to plague, if found to be infected with plague, strict extermination of rats and fleas, isolation and observation and treatment, strengthen personal protection, close contact with people preventive vaccination against plague.