Cough is a protective reflex. Possible causes of uncontrolled coughing include physiologic factors, respiratory tract infections, cough variant asthma, psychiatric factors, and medication factors. 1. Physiological factors: when eating too salty, too acidic food, can stimulate the throat to produce cough, or sudden temperature changes, such as winter to the cold outdoors can trigger cough. 2. Respiratory tract infections: including the upper respiratory tract, such as pharyngitis, can appear in the throat discomfort, foreign body sensation, which induces cough, or the lower respiratory tract, such as pneumonia, pathogenic bacteria infections can damage the respiratory epithelium, causing respiratory mucosal inflammation, cough, coughing up sputum symptoms. 3. Cough variant asthma: belongs to a special type of asthma, only manifested as cough, aggravated at night. 4. Lung malignant tumor: lung cancer can be manifested as cough, with poor effect of applying conventional cough suppressant drugs, which may or may not be accompanied by coughing sputum and wheezing. 5. Pulmonary fibrosis: interstitial pulmonary fibrosis often manifests as dry cough, accompanied by hypoxemia, without obvious sputum. The cause of pulmonary fibrosis needs to be clarified to develop individualized treatment plan. 6. Gastroesophageal reflux disease (GERD): often manifested as acid reflux, heartburn symptoms, gastric acid can be refluxed to the throat to stimulate its coughing symptoms, the application of acid-suppressing drugs such as omeprazole, vonoransen, etc. Significantly improved. 7. Eosinophilic bronchitis: related to inhalation of allergens, harmful substances, the patient mostly manifested as a dry cough, no obvious sputum, sputum eosinophil ratio > 3%, the application of glucocorticosteroids have good results. 8. Mental factors: when emotional excitement, excessive tension, can cause coughing episodes, is due to hyperventilation or vagal reflex. 9. Drug factors: some drugs can cause cough, such as ACEI drugs captopril and so on. When uncontrolled coughing occurs, you should go to the hospital in time to find out the cause of the cough, so as not to delay the condition.