Liver enlargement in leukemia patients is due to extramedullary infiltration of leukemia cells and requires aggressive chemotherapy.
Leukemia is a class of malignant clonal disease of hematopoietic stem cells, which stagnates at different stages of cell development due to enhanced self-renewal, uncontrolled proliferation, impaired differentiation, and blocked apoptosis of leukemia cells. In the bone marrow and other hematopoietic tissues, leukemia cells proliferate and accumulate in large numbers, inhibiting normal hematopoiesis and infiltrating other organs and tissues. The liver may also be involved and become enlarged.
The above situation requires active chemotherapy, but acute leukemia and chronic leukemia treatment drugs and principles are different. Acute myeloid leukemia chemotherapy is based on cytarabine and anthracycline chemotherapy, and acute lymphoblastic leukemia chemotherapeutic drugs also include vincristine, prednisone, and so on.
Chronic granulocytic leukemia is based on oral tyrosine kinase inhibitor imatinib, chronic lymphocytic leukemia, the current main therapeutic drugs are CD20 monoclonal antibody, bendamustine, ibrutinib, etc., and pay attention to hepatoprotective therapy. Generally the hepatomegaly will improve after the primary disease is relieved.
The specific treatment of leukemia hepatomegaly should be decided by professional doctors according to the patient’s own situation. The above drugs should be used under the guidance of a doctor.