Antihypertensive drugs can be broken up into quarter tablets as long as they are not controlled or extended release. When hypertensive patients use antihypertensive drugs for blood pressure control, the dose of the drug needs to be adjusted in a timely manner according to the patient’s blood pressure level and response to the antihypertensive drug in order to maintain a relatively stable blood pressure. When the antihypertensive effect of one tablet of a certain specification is still too strong for the patient, some patients can break the tablet to take the drug, which is not a problem in terms of safety for ordinary tablets, but for controlled-release and slow-release agents, it will destroy the structure of the controlled-release and slow-release, resulting in too large a dose of the drug, which causes hypotension. Although regular tablets can be broken, this is not recommended because the size of the medication varies when broken, resulting in a different dosage for each dose, which is detrimental to stabilizing blood pressure and guiding subsequent medication. Patients can opt for smaller sized preparations or replace them with other types of medication that have a slightly weaker antihypertensive effect.