To test for Stage 1 syphilis, the patient’s blood or the patient’s broken skin exudate can be collected. 1. Blood test: blood is drawn to perfect syphilis serologic examination, including syphilis spirochete specific antibody and syphilis spirochete non-specific antibody, if both results are positive, syphilis can be diagnosed. 2. The patient’s broken skin exudate: you can extract the exudate smear from the patient’s lesion area and observe the presence or absence of syphilis spirochetes under the microscope for determination, which is suitable for patients with syphilis who have skin rashes at an early stage but whose serums are not yet able to detect the corresponding antibodies. Syphilis is a chronic systemic infectious disease caused by syphilis spirochete infection, mainly transmitted through sexual contact. It is recommended to consult a dermatologist at the hospital for timely examination to avoid delay.