Diarrhea with Mesalazine Suppositories may be an adverse reaction caused by the medication, it is recommended to stop using the medication and go to the hospital for examination. Mesalazine suppositories are mainly used for the treatment of ulcerative colitis, which is administered rectally, and may cause adverse reactions such as diarrhea, nausea, vomiting, abdominal discomfort, rash, headache, and diarrhea (discomfort in the lower abdomen, a strong urge to relieve stool, and a feeling of incomplete bowel movement after a bowel movement). Therefore, if diarrhea occurs, it is recommended to stop using the drug. People who are allergic to Liuzosulfapyridine may also be allergic to the drug. People with liver or kidney impairment should use the drug with caution, and the kidney function should be tested regularly when using the drug, if kidney function impairment is found, stop using the drug and go to the hospital for examination. The drug should be used with caution in pregnant or lactating women. The drug should be used under medical supervision.