Fungal spore positivity in men refers to a fungal infection, the severity of which is determined by the type of infection. Clinical fungal diseases can be categorized into two main groups, superficial and deep fungal diseases, depending on the site of invasion. Superficial fungal diseases are generally not serious, while deep fungal diseases are more serious and need to be analyzed specifically. Superficial fungal diseases are caused by dermatophytes that invade the skin, hair and fingernails, and are referred to as ringworm. The deep fungal disease refers to the fungal infection that violates the skin, subcutaneous tissue or systemic tissues and organs below the stratum corneum, and the death rate of deep fungal disease remains high for a long time, which is more serious. 1. superficial fungal disease: men if it is the skin part of the examination found positive fungal spores, then it shows that the skin infection with fungi, this situation is generally not serious, skin fungal infection is a very common disease, need to use naftifine ketoconazole cream and other drugs for treatment. 2. Deep fungal disease: pathogenic fungi are still the most common with Candida and Aspergillus, followed by Cryptococcus and Pneumocystis. It occurs in immunocompromised people with hematologic malignancy, bone marrow transplantation, solid organ transplantation, and high-dose glucocorticoid use. Sensitive antifungal drugs need to be selected as early as possible according to the pathogenic bacteria for treatment. If men are found to be positive for fungal spores, it is recommended that they consult a doctor in time and follow the doctor’s instructions to improve the relevant examination and treatment.