Vaccination redness, swelling, hardness and itchiness is considered to be related to local vaccine absorption, allergy, infection, etc., which can be treated by ice, medication and other means. 1. Local vaccine absorption: may be due to the vaccine injection speed is too fast, resulting in poor local absorption, stimulate tissue proliferation appear red, swollen, hard and itchy phenomenon, generally a normal phenomenon. 2. Allergy: playing vaccine red, swollen, hard and itchy may be allergic to the components of the vaccine, which is manifested as local or even the whole arm appears hard, red, swollen and itchy, can be under the guidance of the doctor orally loratadine tablets levocetirizine hydrochloride tablets, such as antiallergic drug treatment. 3. Infection: may be due to improper care of local skin after the vaccine triggered by local infections, skin redness, swelling, hard lumps and itching and other symptoms, can be coated with tacrolimus ointment, erythromycin ointment under the guidance of a doctor to treat, but also oral antibiotics such as ceftazidime tablets, amoxicillin capsules and other oral antibiotic medication. After vaccination, the symptoms of redness, swelling, hardness and itchiness continue to be unrelieved, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor, to avoid causing other damage.