Normally, patients with gallbladder cancer will not have excessive sputum; if there is an increase in sputum, it may be a combination of gallbladder cancer metastasis to the lungs or the presence of lung disease. If sputum is present in gallbladder cancer patients, it is necessary to further check the patient’s medical history. For example, whether there is blood in sputum, whether there is frequent cough and sputum, whether there is chest pain, chest tightness and hemoptysis. For this situation, the patient needs to undergo relevant examinations, such as CT examination of abdomen and chest, and puncture biopsy if nodular lesions exist. For gallbladder cancer patients with sputum, the following two aspects should be considered: 1. gallbladder cancer combined with lung metastasis: it is necessary to improve relevant examination, confirm the diagnosis and evaluate the condition, and then give chemotherapy, radiotherapy and targeted therapy; 2. Combined lung diseases: commonly lower respiratory tract infections (pneumonia, bronchitis, etc.), lung tumors, etc., which need to be assessed and diagnosed after perfecting relevant examinations such as chest radiographs, CT, blood routine, sputum culture, bronchoscopy, etc., and relevant treatments (e.g., anti-infection, surgical resection, etc.) should be given. If the patient has any discomfort, go to the hospital for examination in time and do not be careless, so as not to delay the treatment and affect the therapeutic effect.