Drinking alcohol during the treatment of H. pylori can have an effect. H. pylori is a kind of bacteria parasitized in the stomach, which is mainly treated by quadruple therapy, such as omeprazole, bismuth potassium citrate combined with amoxicillin and metronidazole. It is not recommended to drink alcohol while taking the medication because the alcohol in wine may damage the gastric mucosa, affect the efficacy of the treatment drugs, and lead to the failure of treating H. pylori. Moreover, H. pylori infection is usually found in patients suffering from chronic gastritis, peptic ulcer and other diseases, and alcohol can damage the gastric mucosa to a certain extent, which is also not conducive to the recovery of the disease. In addition, drinking alcohol while taking cephalosporin antibiotics to treat H. pylori may induce a disulfiram-like reaction, which may even be life-threatening. Patients with H. pylori infection should actively cooperate with their doctors, avoid alcohol and maintain a healthy diet.