The causes of purple lumps in the calf may include trauma, pathological factors, etc. If it is caused by trauma, it can be relieved by physical therapy; if it is a pathological factor, it is necessary to eliminate the cause and apply medication. 1. Trauma: Purple lumps in the calf may be subcutaneous bruises produced by external impact, which is not easy to be detected if the impact occurs by chance. If the patient has obvious pain, cold compresses can be applied to relieve the symptoms within 24 hours, and hot compresses can be applied after 24 hours to promote blood circulation. 2. Pathologic factors: (1) Anaphylactic purpura: If the patient has recurrent purple lumps in the calf, the patient with anaphylactic purpura needs to stop contacting allergens, and then use antihistamines, such as isoprinosine hydrochloride; glucocorticosteroids, such as prednisone, and other treatments. (2) Thrombocytopenic purpura: it can be treated with intravenous gammaglobulin, platelet transfusion, or the application of platelet-promoting drugs, such as Eltrombopag, according to the condition. If the symptoms of purple lumps on the calf do not subside or recur, it is recommended to go to the hospital in time, and the doctor will carry out standardized treatment, and the use of drugs should follow the doctor’s instructions, avoid self-medication.