Closure refers to closed pimples, which are early lesions of acne. The appearance of closed pimples on the face can be eliminated by general treatment and topical medication. 1. General treatment: Choose water or suitable cleansing products to remove excess oil, flakes and bacterial mixtures from the skin surface, and use mild moisturizing lotion externally. Avoid squeezing and scratching the skin lesions with hands. Limit the intake of high glycemic index foods and milk, which may trigger or aggravate acne, keep bowel movement smooth, and avoid staying up late at night. 2. Topical medication: Under the guidance of a doctor, topical adapalene gel, retinoic acid cream and other retinoic acid medications can be applied topically for treatment, which can dissolve keratin and eliminate closed pimples. If you have closed pimples on your face, you should go to the hospital in time and use medication under the guidance of your doctor.