Splenectomy is chosen for ITP patients after 7 months of treatment, the reason may be that the first line treatment such as glucocorticoid and other therapies fail to control the symptoms, so the second line treatment such as splenectomy is chosen. ITP is a group of immune-mediated bleeding disorders caused by excessive destruction of platelets.The first choice of treatment for ITP is glucocorticoid therapy, mostly with prednisone. This is followed by second-line treatments such as splenectomy. If conventional glucocorticoid therapy is ineffective for 4-6 weeks, the disease has been prolonged for more than 6 months, or the glucocorticoid is effective but cannot be tapered, splenectomy is to be considered in such cases, and the effectiveness rate is about 70%. In conclusion, ITP, whether first-line glucocorticoid therapy or splenectomy, should receive regular treatment under the guidance of a doctor.