Knee joint squatting can not stand up may be caused by physiological factors, such as poor blood circulation, etc., may also be due to pathological factors, such as meniscus injury, degenerative knee osteoarthritis. 1. Poor blood circulation: if squatting for a long time, it is possible to make the knee joint blood circulation is not good, the nerve transient ischemia caused by squatting up difficulties. It is recommended to avoid squatting for a long time, stand up and massage properly to relax, the general symptoms will be reduced on their own. 2. Meniscus injury: when the lower limb activity is excessive, it may lead to meniscus injury of the knee, the integrity of the meniscus, the continuity of the meniscus is damaged, when the knee joint activity, the meniscus is compressed and pulled, resulting in pain and squatting can not stand up. 3. Degenerative knee osteoarthritis: it is a kind of knee degenerative lesion caused by long-term wear and tear of the knee joint and degenerative damage of the articular cartilage. As a result, when you stand up from squatting, the knee joint rubs, and the symptoms of joint stiffness, pain, and not being able to stand up will occur. In addition to the above reasons, trauma, rheumatoid arthritis, chondromalacia patellae, etc. may also lead to the knee joint squatting can not stand up. If the knee squatting can not stand up, difficult to self-relief, it is recommended to go to the hospital to further identify the cause of the disease, for standardized, personalized treatment.