Patients with 24-hour urine protein quantification more than 1g are mostly caused by pathological factors, including membranous nephropathy, microscopic lesion nephropathy, various types of glomerulonephritis, etc. The need for hormone therapy is related to the type of the disease, the severity of the disease, and so on.
1. Membranous nephropathy: Membranous nephropathy is antibody-mediated, characterized by the deposition of immune complexes on the epithelial side of the glomerulus, which causes sub-lethal damage to the podocytes and disruption of the glomerular filtration barrier, and ultimately leads to proteinuria and other manifestations of nephrotic syndrome.
Membranous nephropathy is divided into low-risk, intermediate-risk and high-risk groups. Low-risk group (urine protein <4g/d, normal GFR) can not add hormone; intermediate-risk group if there is no contraindication to hormone, usually need to add hormone therapy.
2. Microscopic lesion nephropathy: Microscopic lesion nephropathy refers to a kind of glomerular disease with clinical manifestation of nephrotic syndrome, no obvious pathological changes under light microscope, and fusion of pedunculated cells and peduncles under electron microscope. Microscopic lesion nephropathy is sensitive to hormones and usually requires hormone therapy.
24-hour urine protein quantitative more than 1g, should promptly go to the hospital, under the guidance of professional physicians standardized treatment, do not self-medication.