There are many causes of an enlarged spleen. In the absence of a suspected cause, a number of tests such as routine blood tests, imaging tests and blood tests are usually required to address an enlarged spleen. 1. Blood tests: Since the spleen is directly related to the health of the blood system. Therefore, when abnormal spleen enlargement occurs, the first thing that needs to be done is to conduct routine blood tests. By observing whether the quantity and indexes of various blood components in the blood sample are normal, it can help to determine whether the enlarged spleen has hypersplenism or blood system diseases. 2. Imaging examination: It can directly observe whether the physiological anatomy of the spleen is normal. Therefore, after the spleen is enlarged, timely ultrasound, CT and other imaging observations can determine whether the spleen is enlarged and whether there are abnormalities such as nodules, tumors or tissue necrosis in the abdominal cavity. 3. Blood test: blood biochemistry test can understand the patient’s liver and kidney function, blood electrolytes, nutritional status, etc. Blood tumor marker test can understand whether there are tumors in the body. When abnormal splenomegaly occurs, patients should go to the hospital for examination in time, and follow the doctor’s instructions for treatment after a clear diagnosis.