There is no optimal treatment for erythema multiforme. The causes of erythema multiforme are complicated and related to various factors such as infection, drugs and food, etc. Clinical treatment of erythema multiforme generally involves removing the causes of the disease, and then giving medication to treat the symptoms. 1. Infection: most of erythema multiforme is caused by infection, there are bacterial infection, viral infection, fungal infection and other infectious factors, among which herpes simplex virus infection is a common causative factor, which needs to be treated with medication. For example, bacterial infection can be treated with topical erythromycin ointment; herpes simplex virus infection can be treated with topical acyclovir ointment or oral panciclovir. 2. Drugs: When erythema multiforme is caused by drugs, it is necessary to stop using the suspected drugs and use hormonal ointment such as mometasone furoate cream and halometasone cream to help eliminate erythema multiforme. Oral prednisone and other hormonal drugs can also be taken. 3. Food: When erythema multiforme is caused by certain food, it is necessary to stop eating that food and take oral loratadine and other drugs. Specific erythema multiforme treatment plan should be decided by doctor, and it is recommended to go to regular hospitals in time to find erythema multiforme, and follow the doctor’s instruction to standardize the use of medication, and do not use medication on your own.