Physiological decline in 45-year-old men is mainly manifested in the decline of energy and physical strength, decline in sexual function, emotional depression and memory loss. 1. Decrease in energy and physical strength: easy to get tired, working life, energy and physical strength obviously decline even after rest is difficult to fully recover. 2. Decrease in sexual function: Decrease in sexual desire and function, and obvious fatigue after sex. 3. Emotional depression and memory loss: lack of passion for work and life, emotional depression or short temper, memory loss, easy to forget. In general, men who have the above performance need to consider the possibility of physiological decline, the need to adjust the regularity of life, if necessary, go to the hospital for examination and appropriate medication adjustment.