Methotrexate is not recommended for long-term use, and specific medication should follow the doctor’s instructions. Methotrexate is an antimetabolic antitumor drug, mainly used in the treatment of various types of acute leukemia, especially acute lymphoblastic leukemia, malignant lymphoma, etc. It can also be used in the treatment of head and neck cancer, lung cancer, ovarian cancer and so on. Gastrointestinal reactions such as nausea, abdominal pain, gastrointestinal bleeding are common after taking methotrexate, liver and kidney function impairment, hair loss and other adverse reactions, cough, shortness of breath, pneumonia or pulmonary fibrosis can occur with prolonged use of this product; attention should also be paid to the long-term use of this product will potentially lead to the risk of secondary tumors, and it will have an effect on the reproductive function such as amenorrhea and sperm reduction or deficiency. Therefore, methotrexate is not recommended for long-term use. If you are taking methotrexate, your doctor should evaluate whether to stop or reduce the dosage of methotrexate in conjunction with the patient’s condition.