Sore legs and knees can generally be relieved by hot compresses, medication, physiotherapy or surgery. 1. Hot compresses: If the sore legs and knees are caused by cold, local hot compresses can be applied to improve local blood circulation, which can effectively relieve the discomfort in the legs and knees. 2. Medication: You can take calcium gluconate oral solution to supplement calcium. If it is caused by osteoarthritis of the knee joint, you need to take acetaminophen tablets and other non-steroidal analgesic and anti-inflammatory drugs to relieve the symptoms as prescribed by the doctor. 3. Physical therapy: Under the guidance of doctors and therapists, local microwave physical therapy and infrared therapy can be done to improve muscle tissue metabolism and relieve pain. 4. Surgery: If the joint pain is severe, surgery may be required. The current treatment is knee-preserving treatment, including tibial plateau osteotomy, joint unicondylar replacement, if serious patients can be total knee replacement or total hip replacement, so as to solve the symptoms of pain. Sore legs and knees need to be treated according to the degree of joint degeneration and clinical symptoms of the patient to choose a targeted treatment program and timely treatment. The use of drugs need to follow the doctor’s instructions.