How much glomerular filtration rate of renal insufficiency decreases every year is related to the condition and treatment effect. If the condition is serious and the treatment effect is not good, the glomerular filtration rate may decrease quickly; if the condition is mild and the treatment effect is OK, the glomerular filtration rate decreases slowly, but the specific value varies from person to person and cannot be generalized. Glomerular filtration rate is the amount of plasma fluid filtered out of the glomerulus per unit of time (minute). The glomerular filtration rate of normal adults is generally 80-120ml/min. If the condition of patients with renal insufficiency is severe and the treatment effect is not good, the glomerular filtration rate may decline quickly and progress to the uremic stage; if the patient’s condition is mild and the treatment effect is available to delay the progression of renal function, the glomerular filtration rate declines slowly, but the specific value of the decline varies from person to person, and it is not possible to make a generalization. In addition, with age, especially after 30 years old every 10 years glomerular filtration rate decreased 10ml/(min.1.73m2). Patients with renal insufficiency are advised to visit regular hospitals in time and standardize the treatment under the guidance of doctors.