High serum amyloid in children may occur when there are problems with inflammation and infection in the organism, immune disorders and other problems. 1. Inflammation and infection: serum amyloid is used clinically to detect fever and is a relatively sensitive indicator. When it is elevated, it indicates inflammation and infection, but it is impossible to determine whether there is a viral infection, mycoplasma infection or bacterial infection, and needs to be further confirmed with other tests. 2. Immune diseases: children without signs of infection, but high serum amyloid and high C-reactive protein are considered to be caused by immune diseases, such as systemic lupus erythematosus. Children with high serum amyloid may also have other causes, it is recommended to go to the hospital in time to improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or therapy.