The treatment of chronic pyelonephritis includes general treatment, removal of susceptibility factors, use of antibiotics and so on. 1. General treatment: pay attention to rest, drink plenty of water, urinate frequently, and pay attention to perineal cleanliness in the acute stage. 2. Remove susceptibility factors (1) Urinary tract obstruction: the obstruction should be relieved in time, such as stones, tumors caused by urinary tract obstruction should be surgically treated. (2) Vesicoureteral reflux: anti-reflux can be treated by surgery. (3) Neurogenic bladder: it can be treated by manipulation of urinary drainage, catheterization or surgery. 3. Antibiotics: In acute attacks, if the condition is mild, commonly used drugs such as quinolones (e.g., levofloxacin), semi-synthetic penicillin (e.g., amoxicillin). In severe infections, intravenous ampicillin, cefotaxime, levofloxacin, etc. are required. The above medications should be used according to the doctor’s instructions, and should not be used without authorization, so as not to delay the condition. Patients with chronic pyelonephritis should go to regular hospitals in a timely manner and receive standardized treatment under the guidance of a doctor.