The thickening and hardening of the skin on the soles of the feet may be caused by callus, metatarsal warts, palmoplantar keratosis, etc., which can be treated by general treatment, medication and physical therapy. 1. callus: also called callus, due to the patient’s foot sole skin long-term friction and extrusion, and make the local cuticle thickening and hardening, manifested as the symptoms of the foot sole skin thickening and hardening. Can be appropriate with warm water foot soak, is conducive to the softening of the keratin. You can also use salicylic acid ointment, retinoic acid ointment and other medicines to promote the local keratin loosening and shedding. 2. metatarsal warts: metatarsal warts are benign organisms caused by human papilloma virus infection, often appearing on the soles of the feet, which can be manifested in the soles of the feet skin thickening and hardening of the situation. You can use retinoic acid cream and compound salicylic acid ointment under the guidance of your doctor, which can have a corrosive effect on the warts. You can also use laser, freezing and other physical methods to get rid of warts. 3. Palmoplantar keratosis: It can lead to limited or diffuse hyperkeratosis of the skin on the soles of the feet, which makes the skin on the soles of the feet become thick and hard. You can use vitamin A cream, urea vitamin E cream and other drugs under the guidance of a doctor to moisturize and soften the role of keratin. If the skin on the soles of the feet becomes thick and hard, you need to go to a regular hospital for an examination to clarify the specific cause and then actively carry out the treatment. The above medications should be used in accordance with medical advice.