Hepatic encephalopathy enemas are used to relieve symptoms by means of enemas and are an adjunctive treatment for this condition. Medication and surgery may also be used. Hepatic encephalopathy is a syndrome based on the pathophysiology of metabolic disorders, and enemas are prepared medications that are instilled into the colorectum for the purpose of treating or diagnosing the disease. For patients with hepatic encephalopathy, enemas are an adjunctive therapeutic measure. Commonly used drugs in clinical practice are lactulose, which to a certain extent can effectively alleviate symptoms, acidify the intestinal tract, reduce the absorption of ammonia, and remove toxins from the intestinal tract. In addition, patients with hepatic encephalopathy also need to follow the doctor’s instructions to apply probiotics, prebiotics and other micro-ecological agents, and also need to follow the doctor’s instructions to apply L-ornithine-L-aspartic acid, ornithine-alpha-ketoglutaric acid and other drugs to promote ammonia metabolism in the body. Liver transplantation should be considered for patients with unsatisfactory treatment effect, recurrent symptoms and liver failure. Patients with hepatic encephalopathy need to actively cooperate with doctors to carry out standardized treatment and strengthen disease management to avoid delaying their condition.