The most typical symptoms of the second stage of hemolytic reaction are jaundice and hemoglobinuria. The second stage of hemolytic reaction is due to the lysis of agglutinated red blood cells, which causes a large amount of hemoglobin to be released into the plasma and become plasma and free in the body; at this time, it will lead to jaundice and hemoglobinuria (urine is soy sauce color), and is often accompanied by symptoms such as high fever, chills, respiratory distress, chest pain, rapid heart rate, and drop in blood pressure. At this time, blood transfusion should be stopped immediately, and symptomatic treatment such as raising blood pressure and controlling heart rate should be given if necessary; bilateral lumbar closure can be given to relieve renal tubular spasm to protect the kidneys; and sodium bicarbonate should be injected intravenously to reduce precipitation and alkalinize urine to avoid blocking the renal tubules. Patients with the above symptoms should fully cooperate with the doctor’s treatment, comprehensive assessment of the patient’s condition, active diagnosis and treatment, do not delay the condition, such as the emergence of shock immediately for anti-shock treatment.