Methylcobalamin can be taken together with ibuprofen, but in order to better utilize the effects of the drug, it is recommended to take the drug half an hour apart. Ibuprofen belongs to the anti-inflammatory drugs, has the effect of lowering fever and relieving pain, and methylcobalamin is a kind of drug used for the nutrition of nerves, both of them will not produce pharmacological conflict, so they can be taken at the same time, but in order to play a more effective role in the efficacy of the medicine, it is recommended to take half an hour interval between taking the drug. In addition, neither methylcobalamin nor ibuprofen can be taken as a long-term drug. Long-term use of ibuprofen will cause harm to the body, with various adverse symptoms such as peptic ulcer, vomiting and nausea, impaired liver and kidney function. Adverse reactions to methylcobalamin include allergies, skin rashes in some patients, and severe cases even affecting liver and kidney function. Patients should follow the doctor’s instructions when taking the drug and avoid using the drug privately.