A fever of 38.5 without cough or runny nose may be due to a cold or other diseases, and prompt medical attention is needed. If the fever of 38.5℃ occurs, it may be caused by cold, especially in the epidemic season of influenza virus, after the infection of influenza virus can lead to the emergence of fever, some of the patients’ upper respiratory tract symptoms may not be obvious, if there is no history of other underlying diseases, it is mainly considered to be caused by cold. However, it is also very likely to be caused by other diseases, which can cause fever, such as systemic infection, malignant tumors, connective tissue-vascular diseases, etc. Therefore, fever cannot be immediately ruled out, and it is necessary to consult a doctor in time to conduct a full body examination, and at the same time under the guidance of the doctor to carry out targeted treatment.