The main causes of cold knees and calves are related to anemia, vascular lesions in the lower limbs, and neurological lesions. 1. Anemia: When there is anemia, the blood circulation in the limbs is not smooth, so it will produce the feeling of cold knees and calves. 2. Lower extremity vascular disease: If there are vascular diseases such as varicose veins or deep vein thrombosis in the lower extremity, it will directly affect the blood circulation in the lower leg, which will trigger the symptom of cold knees and lower legs. 3. Neurological lesions: when there are peripheral nerve injuries in the lower limbs or structural changes in the lumbar vertebrae compressing the nerve roots, it is easy to directly affect the sensation of the calf area, resulting in the symptoms of cold knees and calves, and even accompanied by local numbness and pain. Normally, pay attention to the knee and calf warmth, because the cold stimulation will easily lead to aggravation of the symptoms, life should be appropriate exercise. If the symptoms are more obvious, you need to check the cause of the disease, and then follow the doctor’s instructions to standardize the treatment, to prevent the symptoms from aggravating in the later stage, affecting the motor and sensory function of the lower limbs.