High b-type urinary natriuretic peptide should be treated primarily by reducing the cardiac load and removing the triggers that lead to heart failure. Elevated b-type urinary natriuretic peptide is most commonly seen in patients with acute heart failure, and the higher the level, the more severe the heart failure and the greater the risk to the patient. Patients with heart failure should be aware of the requirement to give a reduced cardiac load, and need to be given diuretic therapy, such as furosemide and spironolactone, to expel excess water from the body, and need to be monitored for electrolyte changes during the period of medication. Heart failure is mostly secondary to lung infections, and patients who clearly have lung infections should be given anti-infective medications, such as penicillin antibiotics. Patients with renal insufficiency may also have elevated b-type brain natriuretic peptide, and care should be taken to protect renal function. The level of b-type urinary natriuretic peptide will gradually decrease after the symptoms of heart failure improve, and can be completely normalized in some patients. Patients with chronic heart failure need long-term oral drug therapy and monitoring of b-type urinary natriuretic peptide level.