Involuntary twitching of the thumb may be caused by physiological factors, idiopathic tremor, Parkinson’s disease and other factors. 1. Physiological factors: For example, when you are overworked or mentally overstressed, it may lead to involuntary twitching of the thumbs. It is recommended to adjust the work and rest reasonably, and actively adjust the psychological state, usually can autonomously return to normal, do not need to carry out other treatments. 2. Idiopathic tremor: It is a benign condition and may be related to genetic factors. The thumb and other fingers will shake involuntarily, and the tremor will be aggravated when you are nervous and overworked, which generally does not affect your life. 3. Parkinson’s Disease: It may be related to genetic and neurological factors, and may be manifested as involuntary twitching of the thumb and other parts of the body, and may be accompanied by symptoms such as bradykinesia and myasthenia gravis. There are many possible factors that may cause involuntary thumb twitching, if the symptoms seriously affect your life or the symptoms persist and cannot be relieved on their own, it is recommended that you consult a doctor in a timely manner, complete the relevant examinations, identify the cause of the disease and carry out targeted treatment.