Blepharospasm can be caused by a variety of reasons, according to the different causes of targeted treatment, methylcobalamin as a kind of nutritive nerve drugs, some of the cases of blepharospasm may have an auxiliary therapeutic effect, but should be used in accordance with the doctor’s instructions, do not blindly use the drug. Eye inflammation, visual fatigue, etc. can cause blepharospasm, mainly through the local application of anti-infective drugs, to correct bad eye habits to relieve; for the nervous system function abnormalities caused by blepharospasm, can be taken to medication and surgical treatment, in which the methylcobalamin is not the main medication, but to play a complementary therapeutic effect, more commonly used is botulinum toxin and other drugs. Methylcobalamin adverse reactions include diarrhea, vomiting, nausea, loss of appetite, allergic reactions, etc. It is contraindicated in patients who are allergic to any of the components of the product. It is recommended that patients with blepharospasm should consult a doctor for examination, and after clarifying the condition, take treatment under the guidance of a professional doctor, and do not take medication without authorization.