Increased pulse pressure difference means that the pulse pressure difference is greater than or equal to 60mmHg, which can be considered to be caused by hyperthyroidism, long-term hypertension, rheumatic heart disease, arteriosclerosis, etc. You can take aspirin, metoprolol and other medications according to your condition. 1. Atherosclerosis: according to their own situation, under the guidance of the doctor to take the adjustment of lipid drugs such as simvastatin, anti-platelet drugs such as aspirin, thrombolytic drugs such as streptokinase and anticoagulant drugs such as warfarin. 2. Long-term hypertension: commonly used drugs for hypertension include beta-blockers such as metoprolol and atenolol, calcium channel blockers such as nifedipine and amlodipine, angiotensin-converting enzyme inhibitors such as captopril, and angiotensin receptor antagonists such as candesartan. 3. Rheumatic heart disease: antibiotics such as penicillin is still recognized as the most effective drugs, but also oral glucocorticoids such as prednisone treatment. 3. Hyperthyroidism: commonly used drugs include antithyroid drugs, thioureas such as propylthiouracil and methylthiouracil, imidazoles such as methimazole and carbimazole. Iodine, propranolol, glucocorticoids, etc. can be used if necessary. The occurrence of increased pulse pressure difference should be timely consultation, under the guidance of the doctor for treatment. Nurture a good dietary habits, ensure adequate sleep, do not stay up late, reasonable diet, eat less too greasy food, appropriate exercise.