Irregular bulging of rectum with rough surface is considered to have mucosal lesions, and common causes include rectal cancer, rectal polyps and tuberculosis. 1. Rectal cancer: it is a malignant lesion occurring in the mucosa of rectum, with the proliferation of tissue cells to form soft tissue mass, there will be corresponding changes, often accompanied by thinning of stools, indentation, mucous pus and blood stools and other manifestations. 2. Rectal polyps: some polyps with the increase in size, there will be irregular bulging condition, long time without control, there may be malignant changes, commonly with blood on the stool and other manifestations. 3. Rectal tuberculosis: most of them are caused by tuberculosis of the ileocecal region involving the rectum, forming local caseous granulation tissue, there will be corresponding changes. Often accompanied by low fever, night sweats and other symptoms of tuberculosis poisoning. Rectal irregularities accompanied by bloody stools, change in bowel habits, the need for timely medical examination, diagnosis of the condition after the standardized treatment, to avoid delays in the condition.