Raynaud’s syndrome according to the severity of the course of the drug will vary, the first choice for the use of calcium antagonists, such as nifedipine tablets, severe Raynaud’s phenomenon can be used prostacyclin and its analogs, such as be prostaglandin sodium and so on. Calcium ion antagonists can dilate blood vessels, relieve vasospasm, when used according to the individual’s physique, the possible adverse reactions include anaphylactic edema, vasogenic edema, such as lower limb edema, vasodilatation induced by facial redness, tachycardia, palpitations and so on, and is contraindicated for those who have allergic reactions to nifedipine. Prostacyclin and its analogs have the effect of vasodilating and inhibiting platelet aggregation. Bleeding patients are prohibited. It is recommended that patients avoid prolonged exposure to cold environments, pay attention to body warmth, skin cleanliness and hygiene, avoid contact with irritating objects, and patients must quit smoking to avoid skin vasoconstriction caused by nicotine. Beta-blocking drugs such as metoprolol are contraindicated in Raynaud’s syndrome, and it is specifically recommended to consult a professional physician for advice.