Acne is clinically known as “acne”, acne with hard lumps is usually the formation of cystic or nodular acne, the main usually topical drugs and oral medication, please follow the doctor’s instructions. 1. Topical medication: Tazarotene gel, retinoic acid cream and other retinoic acid drugs, which have the effect of improving the keratinization of follicular sebaceous gland ducts. If necessary, consider giving antibiotics such as fusidic acid cream and clindamycin cream, which are anti-Propionibacterium acnes and anti-inflammatory. 2. Oral medication: For nodular or cystic acne, tetracycline or macrolide antibiotics, such as minocycline, doxycycline, erythromycin, roxithromycin, etc., are often considered. For severe nodular or cystic acne, treatment with intradermal glucocorticoid injections is an option. Acne with hard lumps usually suggests progressive aggravation of the condition, it is recommended that the patient timely consult a doctor to give targeted treatment, do not blindly self-medication. The above medications should be used in accordance with medical advice.