Neocoronavirus refers to a new type of coronavirus pneumonia, which has been mutating until now and will likely continue to do so indefinitely in the future. Because of the relatively poor stability of the ribonucleic acid of the new coronavirus, it is susceptible to genetic mutation during the process of replication and reproduction. In the process of mutation of the new coronavirus, due to the high randomness of the gene mutation, a variety of new coronavirus variants can appear. In order to maintain their own survival, new coronavirus variants need to adapt to the environment through continuous mutation. Therefore, infinite mutations may be required in the future. Although strain mutation has put pressure on the development of vaccines, the technology for vaccine development is now more mature, and virus mutation may result in a gradual decrease in virulence, so there is no need to be overly alarmed about strain mutation. During the outbreak of new coronavirus pneumonia, attention should be paid to wearing masks when going out, disinfecting indoors by wiping with alcohol or chlorine-containing disinfectant, opening windows frequently for indoor ventilation in normal times, and practicing the habit of washing hands frequently to avoid infection with the new coronavirus. For patients who have been diagnosed, in addition to pay attention to cooperate with the medical staff of the treatment, but also need to maintain an optimistic and positive attitude towards life, do not have to hide. Tip: “New coronavirus pneumonia and new coronavirus pneumonia” mentioned in this article were renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.