Cancer prolonged afternoon low fever can be physically cooled if asymptomatic; if there are symptoms such as discomfort and fatigue, medication is needed. Cancer patients with large tumor loads often develop aseptic necrosis, which causes an inflammatory response and prolonged low-grade fever. Prolonged low fever increases consumption, and attention should be paid to supplementing nutrients. For low fever without obvious symptoms, physical cooling such as warm water bath can be considered, which often achieves better therapeutic effect, and patients do not need to worry too much. For patients with low fever with generalized discomfort and fatigue, which has affected the quality of life, medication is needed, such as ibuprofen, indomethacin suppositories and so on. Therefore, cancer low fever is a common clinical symptom, according to the situation, timely treatment, all can achieve better results, but pay attention to supplementation. If there is any discomfort, it is recommended to consult the doctor in time and treat it actively to avoid delaying the condition.