The deterioration time of femoral head necrosis can not be specifically determined, and it has a lot to do with drugs, long time drinking, combined with other underlying diseases and other factors. 1. Drugs: High-dose use of glucocorticosteroids such as prednisolone may cause fat embolism, embolus infarction in the blood vessels in the bone, the local formation of thrombus, which further causes bone marrow necrosis, the destruction of the blood supply of the femoral head, the bone hypoxia, bone cell death leading to the deterioration of necrosis of the femoral head. The specific deterioration time can not be determined, mostly related to individual circumstances. 2. Prolonged alcohol consumption: Alcohol leads to abnormal lipid metabolism in the body, which affects the differentiation ability of bone marrow mesenchymal stem cells and causes necrosis of the femoral head. If the intake of alcohol is not limited after necrosis of the femoral head, the disease may deteriorate within 1 to 4 years. 3. Combination of other underlying diseases: If combined with other underlying diseases such as SLE, anemia, etc., the blood supply to the necrotic femoral head is relatively more reduced, and if there is no active control of the primary disease or intervention in the necrotic femoral head, about 80% of untreated patients will experience femoral head collapse and deterioration of their condition in 1 to 4 years. The deterioration of femoral head necrosis is also related to obesity, smoking, etc. It is recommended to quit smoking, limit alcohol, control body weight and blood lipid, and have regular review for those who have a history of long-term medication and hip trauma.