Frequent leg muscle throbbing should beware of hypocalcemia, lumbar spine disease, Parkinson’s disease. 1. Hypocalcemia: when calcium intake is insufficient, it can enhance neuromuscular excitability, leading to muscle throbbing and spasms in the legs, and muscle pain can also occur. 2. Lumbar spine disease: the leg muscles are mainly innervated by the nerves from the lumbar spine. When there is a lumbar disc herniation or peripheral neuropathy, the local nerves will be compressed, which will reduce the innervating function and lead to symptoms of throbbing of the leg muscles. 3. Parkinson’s disease: Parkinson’s is an extrapyramidal system disease. Parkinson’s is a disease of extrapyramidal system, which is characterized by static tremor, motor retardation, muscle tonus, etc., and symptoms of leg muscle throbbing appear. If the symptoms of frequent leg muscle throbbing can not be relieved for a long time, it is recommended to go to the regular hospital, to clarify the cause of the disease, targeted treatment.