The difference between tonifying Zhong Yi Qi Tang and Si Jun Zi Tang lies in the differences in drug composition, efficacy and main treatment. 1. Composition: tonifying the middle and benefiting the qi is composed of astragalus, atractylodes macrocephala, chenpi, aspergillus, chaihu, ginseng, angelica sinensis, licorice; four gentleman soup is composed of ginseng, atractylodes macrocephala, poria, licorice. 2. Effects: Tonifying the middle Jiao Qi Tang has the effects of tonifying the middle Jiao Qi and elevating Yang to lift the sunken organs; Sijunzi Tang has the effects of tonifying the middle Jiao Qi and strengthening the spleen (regulating the qi of the spleen and stomach). 3. Indications: tonifying the middle Jizi Tang can be used for treating deficiency of Qi in the spleen and stomach, deficiency of Qi in the subsiding organs, and deficiency of Qi in the feverish organs. Sijunzi Tang can be used to treat Qi deficiency in the spleen and stomach. The textbook has not yet recorded the adverse reactions and contraindications of tonifying the middle and benefiting the qi and Si Jun Zi Tang. If necessary, TCM formulas should be used under the guidance of a medical professional who can identify and treat the symptoms.