Type I lupus nephritis usually has a good prognosis and does not need special treatment. When there are manifestations of extra-renal lupus activity or further development of more serious glomerulopathy, timely treatment is needed, and the treatment drugs include glucocorticosteroids, cytotoxic drugs and so on. 1. Glucocorticosteroids: Prednisone acetate tablets are usually chosen for standard treatment, and methylprednisolone can be chosen for the treatment of patients who have developed uremia, and the common adverse effects of methylprednisolone include gastrointestinal discomfort, gastrointestinal ulcers, necrosis of the femoral head, and osteoporosis, etc., which are prohibited during breastfeeding and pregnancy. 2. Cytotoxic drugs: clinical practice has proved that the use of cytotoxic drugs combined with hormone therapy can often achieve better therapeutic efficacy, commonly used drugs such as cyclophosphamide, azathioprine and so on. Common adverse reactions to cytotoxic drugs include allergic reactions such as chills, fever, edema and shock, etc. They are contraindicated during lactation and pregnancy. The application of the above drugs has a certain risk, and need to be applied under the guidance of a specialist. It is recommended that the patient go to the hospital in time and follow the doctor’s instructions to standardize the treatment.