After drinking alcohol, midnight nausea and vomiting may be alcohol stimulation, or chronic gastritis, gastric ulcer and other diseases caused by the need to take general measures, omeprazole, Rebapatide and other medication, surgical treatment for symptomatic and causative treatment. 1. Symptomatic treatment: At this time, you can drink more milk, honey water, you can also eat some warm porridge, such as millet porridge, pumpkin porridge and so on. Those with obvious symptoms need to follow the doctor’s instructions to use omeprazole, rabeprazole and other proton pump inhibitors, and Hâ‚‚ receptor blockers, such as cimetidine, ranitidine and so on. There are also gastric mucosal protective agents, such as Rebapatide, Teprenone and so on. 2. Causal treatment: Generally, patients with nausea and vomiting caused simply by alcohol stimulation of the gastrointestinal tract can be significantly improved after symptomatic treatment. For chronic gastritis and gastric ulcer, if the symptomatic treatment is ineffective, the existence of high-level intraepithelial neoplasia of chronic gastritis patients, need to carry out mucosal stripping; serious symptoms or complications of acute perforation of gastric ulcer patients, need to take the vagotomy or gastrectomy. It is recommended that after drinking alcohol, nausea and vomiting at midnight, patients with obvious symptoms go to the hospital in time to avoid delaying treatment.