Uremia belongs to the end stage of chronic renal failure, which is mainly caused by primary, secondary and hereditary kidney diseases. 1. Primary kidney disease: including chronic glomerulonephritis, chronic interstitial nephritis, chronic pyelonephritis and so on. 2. Secondary kidney diseases: including diabetic nephropathy, hypertensive renal arteriosclerosis, uric acid nephropathy and so on. 3. Hereditary kidney diseases: including polycystic kidney disease, hereditary nephritis and so on. In developed countries, diabetic nephropathy, hypertensive renal small arteriosclerosis is the main cause of chronic renal failure; in developing countries such as China, the most common cause of chronic renal failure is still primary glomerulonephritis, in recent years, diabetic nephropathy caused by chronic renal failure has increased significantly, and it is possible that it will become the primary cause of chronic renal failure in China. Uremic patients should maintain a good state of mind, please do not self-medication, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor standardized treatment.